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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MARK3 All Species: 22.12
Human Site: S478 Identified Species: 44.24
UniProt: P27448 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27448 NP_001122390.1 776 87005 S478 D G I S S R K S S G S A V G G
Chimpanzee Pan troglodytes XP_510184 737 82858 S439 D G I S S R K S S G S A V G G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_868647 777 86967 S479 D G I P S R K S S G S A V G G
Cat Felis silvestris
Mouse Mus musculus Q03141 753 84371 S455 D G I P S R K S S S S A V G G
Rat Rattus norvegicus Q8VHF0 797 88733 S455 D G V P S R K S G S S A V G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508081 736 82480 S447 E G I Q S R K S G S S A V G G
Chicken Gallus gallus Q9IA88 798 88848 P489 H F Y Q H A P P C I V I S S S
Frog Xenopus laevis NP_001084256 725 81522 S451 L K E E V G Q S R K S S S I G
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 Y690 Q P S S H L T Y Q L Q R L R I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 A894 A S S G G A A A A A S A T N Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38997 535 61163 L263 I Y T L P S H L S P G A R D L
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 E359 L S S T M G Y E K D E I Y E S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.7 N.A. 96.4 N.A. 94 89.9 N.A. 90.5 31.4 85.6 26.5 N.A. N.A. N.A. 39.8 N.A.
Protein Similarity: 100 94.7 N.A. 97.4 N.A. 95 91.2 N.A. 92.9 50.7 89.5 42.6 N.A. N.A. N.A. 51 N.A.
P-Site Identity: 100 100 N.A. 93.3 N.A. 86.6 73.3 N.A. 73.3 0 20 6.6 N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: 100 100 N.A. 93.3 N.A. 86.6 80 N.A. 80 0 33.3 13.3 N.A. N.A. N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 27 27.3 N.A.
Protein Similarity: N.A. N.A. N.A. 44 45.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 0 0 17 9 9 9 9 0 67 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % C
% Asp: 42 0 0 0 0 0 0 0 0 9 0 0 0 9 0 % D
% Glu: 9 0 9 9 0 0 0 9 0 0 9 0 0 9 0 % E
% Phe: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 50 0 9 9 17 0 0 17 25 9 0 0 50 59 % G
% His: 9 0 0 0 17 0 9 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 42 0 0 0 0 0 0 9 0 17 0 9 9 % I
% Lys: 0 9 0 0 0 0 50 0 9 9 0 0 0 0 0 % K
% Leu: 17 0 0 9 0 9 0 9 0 9 0 0 9 0 9 % L
% Met: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % N
% Pro: 0 9 0 25 9 0 9 9 0 9 0 0 0 0 0 % P
% Gln: 9 0 0 17 0 0 9 0 9 0 9 0 0 0 9 % Q
% Arg: 0 0 0 0 0 50 0 0 9 0 0 9 9 9 0 % R
% Ser: 0 17 25 25 50 9 0 59 42 25 67 9 17 9 17 % S
% Thr: 0 0 9 9 0 0 9 0 0 0 0 0 9 0 0 % T
% Val: 0 0 9 0 9 0 0 0 0 0 9 0 50 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 9 0 0 0 9 9 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _